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An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides
An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides
Y. R. Baker, C. Thorpe, J. Chen, L. Cox, L. M. Poller, P. Kumar, W. F. Lim, L. Lie, G. McClorey, S. Epple, D. Singleton, M. A. McDonough, J.S. Hardwick, K. E. Christensen, M. J. A. Wood, J. P. Hall, A. H. El-Sagheer, T. Brown
Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides
Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides
A. Dysko, Y. R. Baker, G. McClorey, M. J. A. Wood, G. Williams, A. El-Sagheer, T. Brown
A New 1, 5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility
A New 1, 5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility
S Epple, A Modi, Y. R. Baker, E Wȩgrzyn, D Traoré, P Wanat, A. E. S Tyburn, A. Shivalingam, L. Taemaitree, A. H El- Sagheer, T. Brown
Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification.
Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification.
Y. R. Baker, L. Yuan, J. Chen, R. Belle, R. Carlisle, A. H. El-Sagheer, and T. Brown
Chemically modified nucleic acids and DNA intercalators as tools for nanoparticle assembly
Chemically modified nucleic acids and DNA intercalators as tools for nanoparticle assembly
A.F. De Fazio, D. Misatziou, Y. R. Baker, O. L. Muskens, T. Brown, A. G. Kanaras
Consecutive amide linkages stabilise antisense oligonucleotides and retain an efficient RNase H response
Consecutive amide linkages stabilise antisense oligonucleotides and retain an efficient RNase H response
Y. R. Baker, L. Yuan, J. Chen, R. Belle, R. Carlisle, A. H. El-Sagheer, and T. Brown
Searching for the ideal triazole: Investigating the 1,5-triazole as a charge neutral DNA backbone mimic
Searching for the ideal triazole: Investigating the 1,5-triazole as a charge neutral DNA backbone mimic
Y. R. Baker, D. Traoré, P. Wanat, A. Tyburn, A.H. El-Sagheer, T. Brown
Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation
Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation
J. Chen, Y. R. Baker, A. Brown, A. H. El-Sagheer, T. Brown
Preparation and characterization of manganese, cobalt and zinc DNA nanoflowers with tuneable morphology, DNA content and size
Preparation and characterization of manganese, cobalt and zinc DNA nanoflowers with tuneable morphology, DNA content and size
Y. R. Baker, J. Chen, J. Brown, A. H. El-Sagheer, P. Wiseman, E. Johnson, P. Goddard, T.
Brown
Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs)
Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs)
P. Kumar, L. Truong, Y. R. Baker, A. H. El-Sagheer, T. Brown
Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes
Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes
Y. R. Baker, J. T. Hodgkinson, B. I. Florea, E. Alza, W. R. J. D. Galloway, L. Grimm, S. M.
Geddis, H. S. Overkleeft, M. Welch, D. R. Spring
Development of a multifunctional benzophenone linker for peptide stapling and photoaffinity labelling
Development of a multifunctional benzophenone linker for peptide stapling and photoaffinity labelling
Y. Wu, L. B. Olsen, Y. H. Lau, C. H. Jensen, M. Rossmann, Y. Baker, H. Sore, S. Collins, D. Spring
A new Pseudomonas quinolone signal (PQS) binding partner: MexG
A new Pseudomonas quinolone signal (PQS) binding partner: MexG
J. Hodgkinson, J. Gross, Y. Baker, D. R. Spring, M. Welch.
The Pseudomonas Quinolone Signal (PQS)
The Pseudomonas Quinolone Signal (PQS)
T. Sams, Y. Baker, J. Hodgkinson, J. Gross, D. Spring, M. Welch
Which microbial factors really are important in Pseudomonas aeruginosa infections?
Which microbial factors really are important in Pseudomonas aeruginosa infections?
A. Crousilles, E. Maunders, S. Bartlett, C. Fan, E.-F. Ukor, Y. Abdelhamid, Y. Baker, A. Floto, D. R. Spring, M. Welch
Design and Synthesis of a Biotinylated Chemical Probe for Detecting the Molecular Targets of an Inhibitor of the Production of the Pseudomonas aeruginosa Virulence Factor Pyocyanin.
Design and Synthesis of a Biotinylated Chemical Probe for Detecting the Molecular Targets of an Inhibitor of the Production of the Pseudomonas aeruginosa Virulence Factor Pyocyanin.
Y. R. Baker, W. R. J. D. Galloway, J. T. Hodgkinson, D. R. Spring
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